Polynucleotides (PN)
Polynucleotides are injectable regenerative treatments designed to improve skin quality, hydration, elasticity and the appearance of fine lines by supporting the skin's natural repair and renewal processes.
At Aesculus Clinic, we offer Polynucleotide Treatment in New Malden, including Rejuran®, as part of our personalised approach to regenerative skin health and healthy ageing.
Rather than adding significant volume or changing facial features, polynucleotides focus on improving the condition and quality of the skin itself, making them particularly appealing to patients looking for gradual, natural-looking rejuvenation.
At a Glance
Treatment time: Approximately 30–45 minutes
Sensation: Mild to moderate discomfort
Downtime: Usually minimal, although temporary bumps, swelling or bruising can occur
Best for: Fine lines, crepey skin, reduced elasticity, dullness and declining skin quality
Popular areas: Under eyes, face and neck
Results: Develop gradually as skin quality improves
Treatment course: Usually a course rather than a single treatment
Maintenance: May be recommended depending on your skin and goals
Treatment options: Polynucleotides including Rejuran®
What are polynucleotides?
Polynucleotides are purified fragments of nucleic acids used in injectable treatments designed to support skin repair and regeneration. Unlike traditional dermal fillers, their primary purpose isn't to replace facial volume or reshape facial features.
Instead, polynucleotides are used to improve the environment and quality of the skin, making them particularly interesting within regenerative aesthetics. Depending on your skin and the product selected, treatment may be considered where concerns include fine lines, reduced elasticity, crepey texture, dehydration or declining skin quality.
How Do Polynucleotides Work?
Our skin is constantly undergoing repair and renewal, but these processes become less efficient as we age.
Polynucleotides are thought to support cellular repair processes and fibroblast activity within the skin. Fibroblasts are cells involved in producing important components of the extracellular matrix, including collagen. Rather than producing an immediate filling effect, improvements occur progressively as the skin responds to treatment.
This means polynucleotides are best viewed as a skin-quality and regenerative treatment, rather than a quick cosmetic fix.
Benefits of Polynucleotide Treatment
Depending on your skin and treatment goals, polynucleotides may help:
Improve overall skin quality
Support skin hydration
Improve the appearance of fine lines
Improve crepey or thinning-looking skin
Support skin elasticity
Improve texture
Support regenerative skin processes
Rejuvenate delicate areas such as the under eyes
Create gradual, natural-looking improvements
Improve skin without significantly changing facial volume
What Can Polynucleotides Help With?
Polynucleotide treatment can be considered for several skin concerns.
Fine Lines & Crepey Skin
As collagen, elasticity and hydration decline, the skin may become thinner and develop a crepey appearance. Polynucleotides can form part of a treatment plan designed to improve overall skin quality and resilience.
Under-Eye Skin
The delicate skin around the eyes is one of the most popular areas for polynucleotide treatment.
Treatment may be considered for fine lines, crepey texture and declining skin quality where adding volume with traditional filler isn't necessarily the desired approach.
Skin Elasticity & Texture
Polynucleotides may help support improvements in skin texture, elasticity and overall quality, making them particularly appealing to patients noticing early or progressive changes associated with ageing.
Dull or Tired-Looking Skin
By focusing on skin quality and regeneration, polynucleotides may contribute to skin appearing healthier and more refreshed over time.
Neck & Décolletage
Polynucleotide treatment may also be considered for areas such as the neck where thinning, fine lines and crepey skin become more noticeable.
Polynucleotides for the Under-Eye Area
The under-eye area deserves particular attention because not every under-eye concern should be treated with filler.
Dark circles, hollowness, pigmentation, thin skin, visible blood vessels, fluid retention and skin laxity can all contribute to a tired appearance, and they require different approaches.
Where the primary concern is thin, crepey or poor-quality skin, polynucleotides may be considered because the aim is to improve the skin itself rather than simply adding volume beneath it. However, they won't correct every cause of dark circles or under-eye hollowness.
A proper assessment is therefore important before deciding whether polynucleotides, another treatment or no injectable treatment at all is most appropriate.
Rejuran® Polynucleotide Treatment
Rejuran® is a well-known regenerative injectable treatment associated with the growing Korean approach to improving skin quality and skin health.
Rather than focusing on facial volume, Rejuran is used with the aim of supporting skin repair, texture, elasticity and overall skin quality. It can be considered for areas including the face and delicate under-eye region depending on the specific product, your skin and treatment goals.
At Aesculus Clinic, the decision to use Rejuran or another treatment isn't based simply on which product is currently popular. We assess what your skin actually needs and whether a polynucleotide treatment is the most appropriate way to achieve it.
Polynucleotides vs Skin Boosters: What's the Difference?
This is one of the most common questions patients ask because both treatments are used to improve skin quality.
Skin boosters commonly use hyaluronic acid-based formulations and often have a strong focus on hydration, texture and skin quality.
Polynucleotides use nucleic acid fragments and take a more regenerative approach, supporting biological processes involved in skin repair and renewal. There is overlap between what patients may notice following treatment, but the products and mechanisms are different.
For some patients, hydration is the priority. For others, we may want to focus more strongly on regenerative skin support. In some treatment plans, both approaches may have a role.
Polynucleotides vs Dermal Fillers
Polynucleotides and dermal fillers are very different treatments.
Dermal fillers are generally used when we want to replace or create volume, provide structural support or modify facial contours.
Polynucleotides focus primarily on improving skin quality rather than creating significant volume.
This distinction is particularly important around the eyes. A patient with genuine volume loss may require a very different approach from someone whose main concern is thin or crepey under-eye skin.
Frequently Asked Questions
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Rejuran® is a brand of regenerative injectable treatment within this area. During your consultation, we can discuss the specific product being recommended and why it has been selected for your skin.
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Their primary purpose isn't to create the type of structural volume associated with dermal fillers. The focus is predominantly on improving the quality and condition of the skin.
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Polynucleotides are generally performed as a course rather than relying on one treatment. The exact protocol depends on the product, treatment area and your individual skin.
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This isn't usually an instant-result treatment. Improvements develop progressively as the skin responds, and several weeks may be required before changes in skin quality become more noticeable.
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This varies between patients and depends on the product, treatment area, age, skin condition and lifestyle. Maintenance treatments may be recommended after your initial course.
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Small raised areas can be visible immediately after injection depending on the technique and area treated. These generally settle as the product disperses and the initial swelling reduces.
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Yes, where appropriate. Polynucleotides can form part of a wider skin plan alongside treatments such as skin boosters, microneedling, PRP, anti-wrinkle injections and other skin treatments. They would be appropriately scheduled rather than necessarily performed together.
Good regenerative aesthetics isn't about changing your face. It is about understanding how your skin is changing and selecting treatments that support its quality, resilience and health.
At Aesculus Clinic, Polynucleotide Treatment in New Malden, including Rejuran®, forms part of our personalised approach to skin regeneration and healthy ageing. Whether your concern is under-eye skin, fine lines, crepey texture or declining skin quality, treatment begins by understanding what your individual skin actually needs.